Regenerative Medicine and Stem Cell Therapy

Regenerative Medicine and Stem Cell Therapy

Classification of available Stem Cell Therapies

1.Autograft: Derived from recipient’s own body. Usually derived from Adipose cells but can also come from bone marrow.

2.Allograft: Derived from another human and implanted and/or infused into another. Species to species

3.Xenograft: Different species

All stem cells have 2 minimum qualities:

1.Stems cells are renewable. They undergo mitosis and double approximately every 28 hours for up to 65 generations.

2.Stem cells have potency: Potency is defined as the ability to differentiate into any cell in the body

Umbilical Cord Stem Cells   How They Work

Paracrine: A form of cell to cell communication in which the stem cell produces a signal to induce changes in a nearby cell, altering the behavior or differentiation of those cells. The paracrine factors are secreted in the immediate extracellular environment.

Pericyte: Contractile cells that wrap around the endothelial cells of capillaries and venules throughout the body.

Trophic: Secrete cytokines and growth factors to induce cellular proliferation and angiogenesis.

Main Capacities

Anti-inflammatory: In musculoskeletal trauma, the body releases inflammatory molecules such as IL-1, IL-2, IL-12, TNF-alpha, and INF-gamma, all initiated by the T-1 helper cells.(Pro-inflammatory cells). MSC’s in response secrete an array of anti-inflammatory proteins and immunomodulatory cytokines including PGE-2, tissue growth factor beta-2 (TGF beta-2), hepatocyte growth factor (HGF), nitric oxide, IL-4, IL-6, IL-10 and many more, all initiated by the T-2 helper cells. (anti-inflammatory cells)

Immunomodulatory: Capable of modifying or regulating one or more immune functions. ie. T-1 to T-2 modulation in autoimmune disorders.

Majority of autoimmune disorders are pro-inflammatory (T-1 weighted) thus balancing of the T-1 to T-2 ratio is important

Approximately 20% are T-2 weighted with the same balancing effect

Anti-apoptotic: Apoptosis-Programmed cell death, literally cell suicide.

MSC’s have the ability to rescue apoptotic cells induced by trauma, exposure to hypoxia, chemicals/acidity, mechanical damage or radiation.

Antimicrobial: MSC’s native immune defense against microbial infections is caused by multiple polypeptides. LL37 being the most common and has been shown to be effective against acute, chronic, and systemic infections. MSC’s have also been shown to be effective against protozoa. (Lyme’s disease)


Stem cell Therapy Saftey

Mesenchymal stem cells produce huge quantities of bio-molecules, some of which are immunosuppressive; These cells put up a curtain of molecules around themselves that allows donor (allogenic) stem cells to be transplanted into a recipient, free from an immune response. (Immune privileged) While the body will naturally release TNF-a,   IFN-y, IL-12 and T-1 helper cells to initiate an immune response from the allogenic stem cells, the MSC’s release IL-4, IL-10 and T-2 helper cells to effectively regulate the immune response.

Arnold Caplan, PhD. Case Western Reserve University. Experimental and Molecular Medicine (2013) 45

Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine


Because HUCT stem cells are less mature than other cells, the body’s immune system is unable to recognize them as foreign and therefore they are not rejected. We’ve treated thousands of patients with umbilical cord stem cells and there has never been a single instance of rejection (graft vs. host disease). HUCT stem cells also proliferate/differentiate more efficiently than “older” cells, such as those found in the bone marrow and therefore, they are considered to be more “potent”.

▪Journal of Translational Medicine 2007, Stem Cell Therapy for Autism.

▪Thomas E. Ichim, Fabio Solano, Eduardo Glenn, Frank Morales, Leonard Smith, George Zabrecky, and Neil H. Riordan


HUCT Stem Cell Advantages

  • Anyone can be treated since MSC’s are immune system privileged. No HLA matching necessary
  • Best anti-inflammatory activity, immunomodulatory capacity and ability to stimulate regeneration.

▪Can be administered multiple times in uniform dosages that contain high cell counts. (Dose, frequency, and mode)

▪Dosing: 2-10 M/Kg of body weight

▪Frequency: 2&2. Follow like any other treatment

▪Mode: Intra-articular, I.V., intrathecal, trigger point

▪HUCT stem cells contain an abundant supply of MSC’s.

▪No need to collect stem cells through invasive procedures such as liposuction or bone marrow collection.

▪Consistent quality and quantity regardless of age or health of the patient

▪HUCT MSC’s proliferate/differentiate more efficiently than other types of stem cells and are therefore considered to be more potent.

*   Neil Riordan, Ph.D., Stem Cell Institute, Panama;

** Mehling, Quartararo, et al., Journal of Stem Cell Research, 2015, 5.8



  • A search of website provides information on the more than 4,000 clinical trials being conducted worldwide

Tissue Bank Regulations

▪Allogenic stem cells are considered a tissue and regulated by the AATB.

▪All cells are rigorously tested for diseases, according to tissue bank regulations

▪No expanding of product



▪A stem cell can only be used for a homologous function of the cell. That simply means that a stem cell can only be used for a function that it normally performs in the body, ie. Formation of Tissue, bone, cartilage, blood vessel, nerve, and cell regeneration.


Autoimmune Disorders (122 known)

R.A.  Lupus  Discoid Lupus

Lupus nephritis   Interstit. cystitis   Crohn’s disease

Autism  Cirrhosis  Alopecia areata

Lichen Planus   Psoriasis    Scleroderma

Vitiligo    Addison’s dx  Grave’s dx

Sjogren’s   Endometriosis  Celiac dx

Ulcerative Colitis Blood Disorders  CREST syndrome

Polymyositis  Lyme’s dx  Psoriatic Arthritis

Sarcoidosis  Fibromyalgia  Myasthenia Gravis

MS  Restless Leg  Many Eye Conditions

Meniere’s dx  Kawasaki’s Dx  Vasculitis

Chronic Fatigue  Gastritis  Raynaud’s Phenom.

Ankylosing Spondylitis  Guillain-Barre Syndrome

And many many more

▪Heart Disease


▪Chronic Joint Pain

▪Low Back Pain

▪Bulging or Herniated Discs

▪Spinal Cord Injuries

▪Meniscus, ACL or MCL tears

▪Athletic Injuries

▪Lung Disease: COPD, Asthma, etc.

▪Diabetes Type II

▪Parkinson’s Disease

▪Alzheimer’s Disease


▪Alcohol or Drug Addiction

▪ALS (Lou Gehrig’s dx)

▪Dermatological Conditions

▪Erectile Dysfunction

▪Peyronie’s Disease

▪Accelerates Healing/Reduces Post-Op Inflammation

▪Etc, etc, etc………

Basically, anything that the stem cell naturally does in the body. ie homologous function of the cell


If you have questions or looking for a "WHITE GLOVE- Stem Cell Therapy" service call 1-972-800-6670 (Nationwide) Different services and prices available through out the US, prices are dependant on location. Many of our callers actually travel and save with our Stem Cell THERAPY VACATION! Stem Cell Therapy STEM CELL RESEARCH